Nurse Kevin! What’s up with all the rare ailments you’ve been writing about?? Rare? What do you mean, rare? This school year seems to be the lottery school year for me; I’ve got a whole array of children with ailments that I ain’t ever, never seen (or even heard of). And, if you’re anything like me, you haven’t heard about these ailments either. But after today, you’ll know a bunch more about Cerebral Creatine Deficiency Syndromes (CCDS). We’ll just stick with “CCDS” from now on (but I’ll throw in a few Cerebral Creatine Deficiency Syndromes (CCDS)’s for SEO).
First Of All
What is Creatine? Okay…wait…what is Creatinine? Check my spelling of creatine vs Creatinine. Now, I know good and dog-on well ‘least one of y’all get stumped on this. I’ll make this me as clear as mud? Are you ready? Here we go:
The best way I know to describe the creatine vs creatinine is a comparison to something simple. Okay, if creatine is “food” for muscles, creatinine is the “poop.” Let me do a little better job:
Creatine is an amino acid. If you were looking for creatine in the body, you’d find it being stored in the muscles and in the brain but being created in the body’s liver, pancreas and kidneys. You’d get a bit extra creatine if you eat seafood and red meat. Not a seafood or red meat eater? You’d find PLENTY of the stuff at any health food store. For most people, creatine supplements are not necessary because creatine is not an essential amino acid.
Creatine is responsible for energy. To put it simply, our body does “magic” things to creatine and stores it in our muscles. Then, when we need energy, we have creatine there waiting and willing to provide that extra boost of energy. Yes, there’s more to it. But that information is way (WAY) beyond the scope of this article.
When muscles work, creatine is “used” for “food” and creatinine, a “chemical waist molecule” is what’s left over (the poop). And everyone has creatinine in the body “in line” to be excreted from the body through one of the body’s “washing machines:” The Kidneys .
Cerebral creatine deficiency syndromes (CCDS)
Cerebral Creatine Deficiency Syndromes (CCDS) are inborn errors of creatine metabolism which interrupt the formation or transportation of creatine. Notice I used the plural form of “Syndromes.” CCDS refer to three specific syndromes.
Guanidinoacetate Methyltransferase Deficiency (GAMT)
Arginine: Glycine Amidinotransferase Deficiency (AGAT)
I’ve talked about creatine being stored in the brain and the muscles. And when the muscles work, creatine is used and creatinine is produced as a waste product. Considering the brain NEEDS creatine to function like the muscles need creatine to function (not in the same manner but function nonetheless). CCDS are genetic conditions in which there is an insufficient amount of creatine in the brain. How this happens is a long story (another topic outside the scope of this article). Basically, we have a gene called SLC6A8. SLC6A8 is a Protein Coding gene. BIG JOB!! Like coding a computer program, SLC6A8 writes code…instructions…on how to make a protein that transports the creatine into cells.
It’s kind of like instructions on building a truck. Let’s say the truck builder needs instructions on how to build a truck with the ability to haul Thanksgiving turkeys to the market. If parts of the instructions are mixed up or missing. The truck builder ends up building a truck without sides on the truck bed. On the way to market, the turkeys fall out of the truck. This ends up in lost turkeys. Not all of the Thanksgiving turkeys get to the market. When the store’s customers show up to buy Thanksgiving Turkeys, there ain’t enough to go around and things end up being not-so-good for some folks on Thanksgiving Day.
When there are “problems” with the gene: SLC6A8, there is an impairment in the transporter protein. If the transporter protein can’t bring creatine into cells, a creatine shortage is the result (not enough Thanksgiving Turkeys). A creatine deficiency will present itself in areas of the body that require a bunch of energy to function properly: The Muscles and the EVER IMPORTANT Brain.
To sum up this explanation a bit better…and considering the three syndromes:
Creatine Transporter Deficiency (CTD) – there is a defect in the TRANSPORTER OF CREATINE. Result: Shortage of Creatine. The creatine is there; it just can’t get to the right places.
Guanidinoacetate Methyltransferase Deficiency (GAMT) and in Arginine: Glycine Amidinotransferase Deficiency (AGAT) – there is a mutation in the gene that MAKES the enzyme that MAKES creatine. Result: Shortage of Creatine. There’s not enough creatine being created.